Product Description
Butyl rubber, derived synthetically from petrochemicals, is a copolymer of isobutylene, and to a smaller extent, isoprene. Subsequent halogenation results in a halobutyl rubber – typically bromobutyl or chlorobutyl. Mainly used with glass vials and large infusion bottles, with aluminum caps or aluminum-plastic(flip-off) caps.
1. High cleanliness standard. Production under 100,000 class cleaning area,
2. Superior service system, with professional technical personnel, to provide customers with supporting and personalized services at any time;
3. Supply well-known pharmaceutical manufacturers home and abroad.
4. Core material: rubber from exxon mobi, these rubbers have excellent properties of durability, elasticity, and resilience.
5. Size and color: Customize
Many modern rubber formulations used in the pharmaceutical industry for caps (stoppers and plungers) use bromobutyl rubber as a base. Compared to other rubbers, bromobutyl rubber is usually lower in extractables and has excellent resistance to water and oxygen penetration. However, when selecting the most suitable rubber formulation for a plug or plunger, it is important to remember that the formulation contains more than just bromobutyl rubber - it also includes fillers, vulcanizing agents, antioxidants, pigments, etc. The sum of these ingredients, and the way in which the blend is made, gives the formulation its properties.
Having the right bromobutyl rubber, but not the right additives for the complete formulation, will result in poor performance. Having the right formulation and understanding the needs of the drug, such as compatibility with the formulation and long-term stability, will help achieve high performance.
Xiangyi has many bromobutyl rubber stoppers for sale, if you need them, please contact us!
Bromobutyl Rubber: is a terpolymer of isobutylene, isoprene and brominated Isoprene.
► Processing
When bromine is used as the halogen for producing bromobutyl rubber, it is generally added at a concentration of 2%;
Bromine is more reactive than Chlorine, so a stabilizer is often added to the rubber (such as soybean oil at 1.3%).
The use of antioxidants (such as BHT) is approximately equal in both bromobutyl rubber and chlorobutyl rubber.
► Advantages and Disadvantages
Advantages
lower hygroscopicity and is a better choice for freeze dried / lyophilization product applications. Higher stability and generally have a longer shelf life.
faster cure rates and a shorter scorch or cure induction period (more efficient production)
requires lower levels of curatives and enables one to use a wider range of accelerators.
Disadvantages
stabilizers are required in the production of bromobutyl rubber (such as soybean oil).
heat sensitivity is a greater concern with bromobutyl stoppers.
Chlorobutyl Rubber: is a terpolymer of isobutylene, isoprene and chlorinated Isoprene.
► Processing
chlorine is added at a concentration of 1.1 – 1.5% in chlorobutyl rubber.
Chlorine, being more inert, does not require the use of any stabilizers.
► Advantages and Disadvantages
Advantages
better resistance to heat and is the preferred stopper for high-heat sterilization techniques.
efficiently produced without the use of stabilizers.
Disadvantages
longer curing times, resulting in higher production costs
● Advanced production system combines independent & cooperative research & development.
● Self inspection indicators
● 5 levels of 80-meter automatic cooling system.
● R&D system and central lab are according to international tech development direction and meet customers’ demand.
● 100 sets of advanced testing instruments and inspecting equipment.
● GMP CERTIFICATION
● SGS MSDS CERTIFICATIONS
● CFDA REGISTRATION
● BSE TSE CERTIFICATIONS
● CYTOTOXICITY TESTS REPORTS
Inner packing: Tyvek bag or double layer PP bag
Outer packing: Corrugated carton on pallets with shrink wrap
Automatic stock system
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